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What
causes unilateral vocal fold paralysis?
Most unilateral paralysis of the vocal folds happens
for one of three reasons: nerve injury during a number
of common surgeries, pressure on the nerve from a tumor
growing next to it, or inflammation that stops the
nerve from working, usually attributed to viral infection.
Together, these three scenarios account for more than
85% of cases of paralyzed vocal folds. There are dozens
of other less common causes like stroke and other neurologic
disease, and side effects of certain drugs and toxins.
Vocal fold paralysis may be an inadvertent result of several
common surgeries, listed in the table. These include heart and
lung operations, because the principal nerve of the vocal folds
dips into the chest before returning to the larynx. Paralysis
of the vocal fold is not necessarily a sign that the nerve has
been cut. The nerve may also stop working if stretched or squeezed,
and sometimes after surprisingly little handling. For this reason
a vocal fold may be paralyzed after even the smoothest of operations.
Finally, branches of the nerve may also be damaged by the breathing
tube put in for general anesthesia.
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Surgeries which
may result in vocal fold paralysis:
Thyroid surgery
Carotid endarterectomy
Spinal
surgery in the neck (anterior
cervical diskectomy)
Mediastinoscopy
Esophagectomy
Cardiac
surgery (especially
aortic valve surgery)
Lung
surgery (usually only
on the left)
Repair of aortic aneurysms in the chest
Thymectomy
Brain surgery for aneurysm
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In
cases of paralysis in persons who have not had surgery that
may damage the nerve, tumors are the most serious concern,
with health consequences that reach far beyond voice. Radiologic
studies that look over the entire path of the nerves to the
larynx, including the chest, are essential.
The consensus is that a CT (or CAT) scan of the neck and chest
with contrast dye is the minimum study required to examine
the nerves adequately. Lung cancers are the most common tumors
to cause vocal fold paralysis.
In
some 15-20% of cases, no reason is found for the vocal fold
paralysis, even after appropriate radiologic studies. These
are called idiopathic ,
and usually attributed to viral inflammation. It is important
to understand
that this is only an assumption.
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Finding
a cause for a paralyzed vocal fold can be simple, as in hoarseness
that occurs immediately after a neck surgery, or very challenging.
A meticulous history is
the most important element in this search, aided by appropriate
scans, which include
the chest. A diagnosis of idiopathic vocal fold can only
be made after all other possibilities have been eliminated.
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What
are the symptoms of unilateral vocal fold paralysis?
In unilateral paralysis, the vocal folds are unable to close, which causes voice
and swallowing problems. The voice is hoarse, breathy and soft, and speaking
above background noise is a challenge. Patients get winded when speaking, because
so much air is needed to make the vocal folds vibrate. This is commonly mistaken
for shortness of breath caused by a lung problem by both doctors and patients.
Sometimes, muscles not usually involved in voicing will act to try to bring the
vocal folds together, which can give a person a sore neck after prolonged speaking.
Occasionally, voice changes will be accompanied by coughing when swallowing.
This is especially noticeable when drinking liquids.
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Figure
1A (left): The vocal
fold on the right of this photo is paralyzed after
a thyroid operation.
Figure
1B (right): An
effort to make voice moves the other fold to the
midline, but
a substantial
gap remains between the two. This makes
for a soft, breathy voice.
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What
does unilateral vocal fold paralysis look like?
Vocal fold paralysis is diagnosed by a lack
of movement in a vocal fold. Sometimes this is obvious,
but the activity of neighboring muscles may occasionally
give the illusion of vocal fold motion. Putting the larynx
through a series of motions such as repeated voicing and
sniffing will usually clear up any confusion.
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In
recent years, it has become clear that vocal folds may be
only partially paralyzed. This is called “paresis” and,
because the vocal fold retains some ability to move, can
be especially challenging to diagnose. Vocal fold paresis
is one of the most commonly overlooked diagnoses in laryngology.
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Figure
2A (left): The vocal
fold on the right of the photo is paralyzed. .
Figure
2B (right): Even
with extreme effort, the opposite vocal
fold cannot meet its partner.
 
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How is unilateral vocal fold paralysis treated?
Some cases of vocal fold paralysis recover
by themselves. Neither resting the voice nor exercising
the vocal folds has been shown to have any effect on
recovery. Similarly, no medicine has been proven to help,
though some otolaryngologists will prescribe steroids
in the belief that they reduce inflammation that has
caused the nerve to stop working. It is reasonable to
try voice therapy while waiting for the nerve to recover,
in order to learn how to obtain the best voice in the
meantime.
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Many
otolaryngologists recommend waiting 6 months or a year to
allow for vocal fold paralysis to clear up on its own before
performing corrective surgery. This interval of time is determined
largely by tradition – there is almost no evidence
to support this practice. The appropriate interval should
be determined individually in each case, based to extent
of disability, likelihood of recovery and vocal
demand.
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physicians have found a test known as electromyography (EMG) to be
useful, both to diagnose paralysis and help determine how likely
it is that it will recover on its own. EMG is performed by putting
needles into the muscles of the larynx through the skin of the neck
for a few minutes to record electrical activity. EMG results are
not always straightforward, “yes-or-no” type information,
but are often very helpful in making subtle diagnoses and treatment
decisions. In most cases of unilateral vocal fold paralysis, it is possible
to restore near-normal conversation voice, even though, so far,
it has not been possible to restore motion to an immobile vocal
fold. Treatment is based on repositioning the immobile vocal fold
closer to its partner. This is known as medialization. The details
of this are addressed in the treatment section. In brief, though,
it can be accomplished by injecting the vocal fold with one of
a number of available substances (injection
medialization), or
by placing a block of artificial material into the larynx through
an operation on the outside of the neck (medialization
laryngoplasty).
Sometimes, this second procedure also involves repositioning the
laryngeal cartilages. Each technique has its own advantages and
disadvantages, and making an intelligent choice among available
treatments depends on discussing these in detail with your physician.
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Teflon™ was
once commonly injected into the vocal folds for vocal fold
paralysis. Teflon™ has been found to cause irritative
growths called granulomas after a time, which usually have
to be surgically removed. For this reason, it has been abandoned
by most laryngologists. Any physician who proposes to use
Teflon™ should explain clearly why it is preferable
to another procedure.
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